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研究成果

许丽艳教授(5篇代表性文章)

1.Zheng ZY# , Yang PL#, Luo W, Yu SX, Xu HY, Huang Y, Li RY, Chen Y, Xu XE, Liao LD, Wang SH, Huang HC, Li EM*, Xu LY*. STAT3β Enhances Sensitivity to Concurrent Chemoradiotherapy by Inducing Cellular Necroptosis in Esophageal Squamous Cell Carcinoma. Cancers (Basel). 2021 Feb 21;13(4):901.

2.Pan F, Xu X, Zhang LL, Luo HJ, Chen Y, Long L, Wang X, Zhuang PT, Li EM*, Xu LY*. Dietary riboflavin deficiency induces genomic instability of esophageal squamous cells that is associated with gut microbiota dysbiosis in rats. Food Funct. 2020 Nov 18;11(11):10070-10083.

3.Zhan XH#, Jiao JW#, Zhang HF, Xu XE, He JZ, Li RL, Zou HY, Wu ZY, Wang SH, Wu JY, Liao LD, Wang JJ, Cheng YW, Zhang K, Neufeld G, Xu LY*, Li EM*. LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion. Cancer Res. 2019 Oct 1;79(19):4951-4964.

4.Zhang XD, Huang GW, Xie YH, He JZ, Guo JC, Xu XE, Liao LD, Xie YM, Song YM, Li EM*, Xu LY*. The interaction of lncRNA EZR-AS1 with SMYD3 maintains overexpression of EZR in ESCC cells. Nucleic Acids Res. 2018;46(4):1793-1809. 

5.Long L, Pang XX, Lei F, Zhang JS, Wang W, Liao LD, Xu XE, He JZ, Wu JY, Wu ZY, Wang LD, Lin DC, Li EM*, Xu LY*. SLC52A3 expression is activated by NF-κB p65/Rel-B and serves as a prognostic biomarker in esophageal cancer. Cell Mol Life Sci. 2018;75(14):2643-2661.


宋旭红教授(5篇代表性文章)

1.Songgang Gu#, Xuhong Song#, Rufei Xie, Cong Ouyang, Lingzhu Xie, Qidong Li,Ting Su, Man Xu, Tian Xu, Dongyang Huang*, Bin Liang*. Berberine inhibits cancer cells growth by suppressing fatty acid synthesis and biogenesis of extracellular vesicles. Life Sciences. 2020,257:118122.

2.Song X, Huang D, Liu Y, Pan X, Zhang J, Liang B*. AMP-Activated Protein Kinase Is Required for Cell Survival and Growth in HeLa-S3 Cells In Vivo. IUBMB Life. 2014; 66(6):415-23.

3.Yan Y, Song X*, Liu G, Su Z, Du Y, Sui X, Chang X, Huang D*. Human NRDRB1, an Alternatively Spliced Isoform of NADP(H)-Dependent Retinol Dehydrogenase/Reductase Enhanced Enzymatic Activity of Benzil. Cell Physiol Biochem. 2012; 30(6): 1371-82.

4.Song XH#, Liang B#, Liu GF, Li R., Xie JP, Du K and Huang DY*. Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/ reductase with deletion of exon 3 in cervical squamous carcinoma. International Journal of Cancer. 2007;120(8):1618 -26. 

5.Liang B#, Song XH#, Liu GF, Li R, Xie JP, Xiao LF, Du MD, Zhang QX,Xu XY, Gan XQ, Huang DY*. Translocation of TR3/Nur77 to the Endoplasmic Reticulum is involved in ER Stress-induced Apoptosis. Experimental Cell Research. 2007;313(13): 2833-44. 


程银伟副研究员(5篇代表性文章)

1.Cheng YW, Shabir G, Li X, Fang LP, Xu LY, Zhang HF, Li EM. Development of a deep-red fluorescent glucose-conjugated bioprobe for in vivo tumor targeting. Chem Commun. 2020; 56(7):1070-1073.

2.Cheng YW, Chen YM, Zhao QQ, Zhao X, Wu YR, Chen DZ, Liao LD, Chen Y, Yang Q, Xu LY, Li EM, Xu JZ. Long Read Single-Molecule Real-Time Sequencing Elucidates Transcriptome-Wide Heterogeneity and Complexity in Esophageal Squamous Cells. Front Genet. 2019;10:915.

3.Cheng YW, Liao LD, Yang Q, Chen Y, Nie PJ, Zhang XJ, Xie JJ, Shan BE, Zhao LM, Xu LY, Li EM. The histone deacetylase inhibitor panobinostat exerts anticancer effects on esophageal squamous cell carcinoma cells by inducing cell cycle arrest. Cell Biochem Funct. 2018;36(8):398-407.

4.Cheng Y, Xie J, Zeng F, Nie P, Wu B, Du Z, Pan F, Wu J, Xie L, Zhang P, Xu X-e, Liao L, Xie Y, Shen J, Wu Z, Peng Y, Xu Y, Xie W, Wang S, Lin X, Fu J, Zheng C, Tao L, Fang W, Xu L, Li E. Fascin and esophageal squamous cell carcinoma. Prec Radiat Oncol. 2017;1(3):82-87.

5.Cheng Y, Zhu W, Chen Y, Ito S, Asami T, Wang X. Brassinosteroids control root epidermal cell fate via direct regulation of a MYB-bHLH-WD40 complex by GSK3-like kinases. eLife. 2014;3:e02525. 


李英辉老师(代表性文章)

1.Li YH, Choi DH, Lee EH, Seo SR, Lee S, Cho EH. SIRT3 regulates α-SMA    production through the succinate dehydrogenase-GPR91 pathway in hepatic stellate cells. J Biol Chem. 2016 Feb 24. 

2.Li YH, Woo SH, Choi DH, Cho EH.Succinate causes  α-SMA production through GPR91 activation in hepatics stellate cells. Biochem Biophys Res Commun. 2015 Aug 7;463(4):853-8. 

3.Kim JH. Jang JW  Lee YS. Lee  JW Chi XZ. Li YH. Kim MK. Kim DM. Choi BS.RUNX family members are covalently modified and regulated PIAS1-mediated sumoylation. Oncogene 2014 Apr 28;3: 

4.Lee YS, Lee JW, Jang JW, Chi XZ, Kim JH, Li YH, Kim MK, Kim DM, Choi BS, Kim EG, Chung JH, Lee OJ, Lee YM, Suh JW, Chuang LS, Ito Y, Bae SC. Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma. Cancer Cell. 2013;24(5):603-16 

5.Goh YM. Cinghu S. Hong ET.  Lee YS.  Kim JH.  Jang JW. Li YH. Chi XZ.  Lee KS. Wee H. Ito Y. Oh BC. Bae SC.Src kinase phosphorylates RUNX3 at tyrosine residues and localizes theprotein in the cytoplasm. J Biol Chem. 285(13):10122-9. 2010


谢晓俊老师(5篇代表性文章)

1.Wu Xu, Xiao-Jun Xie, Ali K. Faust, Mengmeng Liu, Xiao Li, Feng Chen, Ashlin A. Naquin, Avery C. Walton, Peter W. Kishbaugh, Jun-Yuan Ji (2020) All-Atomic Molecular Dynamic Studies of Human and Drosophila CDK8: Insights into Their Kinase Domains, the LXXLL Motifs, and Drug Binding Site. - International Journal of Molecular Sciences, 21(20): 7511.

2.Xinsheng Gao, Xiao-Jun Xie, Fu-Ning Hsu, Xiao Li, Mengmeng Liu, Rajitha-Udakara-Sampath Hemba-Waduge, Wu Xu, Jun-Yuan Ji (2018) CDK8 Mediates the Dietary Effects on Developmental Transition in Drosophila. - Developmental Biology, 444(2): 62-70

3.Tianyi Zhang*, Fu-Ning Hsu*, Xiao-Jun Xie* (Co-first), Xiao Li, Xinsheng Gao, Xun Pei, Yang Liao, Wei Du, and Jun-Yuan Ji (2017) Reversal of Hyperactive Wnt Signaling-Dependent Adipocyte Defects by Peptide Boronic acids. - PNAS, 114: E7469-E7478.

4.Xiao-Jun Xie, Fu-Ning Hsu, Xinsheng Gao, Wu Xu, Jian-Quan Ni, Yue Xing, Liying Huang, Hao-Ching Hsiao, Haiyan Zheng, Chenguang Wang, Yani Zheng, Alus M Xiaoli, Fajun Yang, Sarah E Bondos, Jun-Yuan Ji (2015) CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila. - PLoS Biology, 13(7): e1002207

5.Yani Zheng, Fu-Ning Hsu, Wu Xu, Xiao-Jun Xie, Xinjie Ren, Xinsheng Gao, Jian-Quan Ni, Jun-Yuan Ji (2014) A developmental genetic analysis of the lysine demethylase KDM2 in Drosophila melanogaster. - Mechanisms of Development, 133: 36-53


龙琳老师(5篇代表性文章)

1.Long L, Pang XX, Lei F, Zhang JS, Wang W, Liao LD, Xu XE, He JZ, Wu JY, Wu ZY, Wang LD, Lin DC*, Li EM*, Xu LY*. SLC52A3 expression is activated by NF-κB p65/Rel-B and serves as a prognostic biomarker in esophageal cancer. Cellular and Molecular Life Sciences. 2018;75(14):2643-2661. PubMed PMID: 29428966. DOI: 10.1007/s00018-018-2757-4. IF=7.014.

2.Long L, He JZ, Chen Y, Xu XE, Liao LD, Xie YM, Li EM*, Xu LY*. Riboflavin depletion promotes tumorigenesis in HEK293T and NIH3T3 cells by sustaining cell proliferation and regulating cell cycle-related gene transcription. The Journal of nutrition. 2018;148(6):834-843. PubMed PMID: 29741716. DOI: 10.1093/jn/nxy047. IF=5.075.

3.Pan F, Chen Y, He JZ, Long L, Chen Y, Luo HJ, Xu YW, Pang XX, Yang Q, Wang JJ, Xu XE, Wang SH, Li EM*, Xu LY*. Dietary riboflavin deficiency promotes N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by inducing chronic inflammation. Am J Cancer Res. 2019;9(11):2469-2481. SCI-IF=4.7

4.Peng L, Guo JC, Long L, Pan F, Zhao JM, Xu LY*, Li EM*. A Novel Clinical Six-Flavoprotein-Gene Signature Predicts Prognosis in Esophageal Squamous Cell Carcinoma. Biomed Res Int. 2019;2019:3869825. SCI-IF=2.9

5.Pan F, Zhang LL, Luo HJ, Chen Y, Long L, Wang X, Zhuang PT, Li EM*, Xu LY*. Dietary riboflavin deficiency induces ariboflavinosis and esophageal epithelial atrophy in association with modification of gut microbiota in rats. European Journal of Nutrition. 2020. DOI:10.1007/s00394-020-02283-4. SCI-IF=4.7 


获得的专利

序号

专利名称

发明人

授权时间

专利号

1

人食管癌细胞ezrin基因启动子

许丽艳,高书颖,李恩民

2008.10.22

ZL200610036995.2

2

人食管癌细胞ezrin基因上游转录调控元件

许丽艳,高书颖,李恩民

2009.01.28

ZL200610123684.X

3

人食管癌细胞fascin基因启动子区调控元件

许丽艳,郭张燕,高书颖,杨章民,谢剑君,李恩民

2009.03.04

ZL200710026290.7

4

抑制人ezrin基因表达的siRNA在食管癌细胞移动侵袭研究中的应用

许丽艳,谢剑君,李恩民

2010.07.28

ZL200610037493.1

5

抑制人ezrin基因表达的siRNA在食管癌细胞增殖研究中的应用

许丽艳,谢剑君,李恩民

2011.01.07

ZL200610037492.7

6

抑制人ezrin基因表达的siRNA及其表达载体

许丽艳,谢剑君,李恩民

2011.06.08

ZL200610037491.2

7

Kindlin-2Myosin-9Annexin II三蛋白联合预测食管癌患者预后试剂盒

许丽艳,曹卉慧,许秀娥,吴健谊,李恩民

2016.06.08

ZL201410693622.7

8

CD105esVEGFMYC三蛋白联合预测食管癌患者预后试剂盒

许丽艳,陈博,许秀娥,吴健谊,李恩民

2018.06.29

ZL201610462797.6