临床药学教研室
研究成果

1. Che Z, Zhou Z, Li SQ, Gao L, Xiao J, Wong N K. ROS/RNS as molecular signatures of chronic liver diseases. Trends Mol Med 2023 Nov, 29 (11), 951-967.

2. Fang X, Huang W, Sun Q, Zhao Y, Sun R, Liu F, Huang D, Zhang Y, Gao F, Wang B. Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation. Life Sci. 2023 Nov 1;332:122108.

3. Shafiq M, Bilal H, Permana B, Xu D, Cai G, Li X, Zeng M, Yuan Y, Jiao X, Yao F. Characterization of antibiotic resistance genes and mobile elements in extended-spectrum β-lactamase-producing Escherichia coli strains isolated from hospitalized patients in Guangdong, China. J Appl Microbiol. 2023 Jun 19:lxad125.

4. Sun J, Yuan Y, Cai L, Zeng M, Li X, Yao F, Chen W, Huang Y, Shafiq M, Xie Q, Zhang Q. Metagenomic evidence for antibiotics-driven co-evolution of microbial community, resistome and mobilome in hospital sewage. Environ Pollut. 2023 Jun 15;327:121539.

5. Wang W, Wong N K, Bok S L, Xu Y, Guo Y, Xu L, Zuo M, St Croix C M, Mao G, Kapralov A, Bayir H, Kagan V E, Yang D. Visualizing cardiolipin in situ with HKCL-1M, a highly selective and sensitive fluorescent probe. J Am Chem Soc. 2023 May 24;145(20):11311-11322.

6. Chen T, Ren C, Wong N K, Yan A, Sun C, Fan D, Luo P, Jiang X, Zhang L, Ruan Y, Li J, Wu X, Huo D, Huang J, Li X, Wu F, E Z, Cheng C, Zhang X, Wang Y, Hu C. The Holothuria leucospilota genome elucidates sacrificial organ expulsion and bioadhesive trap enriched with amyloid-patterned proteins. Proc Natl Acad Sci U S A. 2023 Apr, 120 (16), e2213512120.

7. Yuan Y, Zeng M, Sun J, Li X, Yao F, Shafiq M, Guo X, Wang M, Lu T, Wong NK, Li AJ. Metagenomic insights into antibiotic resistance-related changes in microbial communities, resistome and mobilome under a modified A2/O treatment process for hospital sewage. Journal of Environmental Chemical Engineering. 2023 Feb 1;11(1):109216.

8. Noman SM, Shafiq M, Bibi S, Mittal B, Yuan Y, Zeng M, Li X, Olawale OA, Jiao X, Irshad M. Exploring antibiotic resistance genes, mobile gene elements, and virulence gene factors in an urban freshwater samples using metagenomic analysis. Environmental Science and Pollution Research. 2023 Jan;30(2):2977-90.

9. Ohore OE, Wang Y, Wei Y, Sanganyado E, Shafiq M, Jiao X, Nwankwegu AS, Liu W, Wang Z. Ecological mechanisms of sedimental microbial biodiversity shift and the role of antimicrobial resistance genes in modulating microbial turnover. Journal of Environmental Management. 2023 Jan 1;325:116547.

10. Mo X M, Pan Q, Seifert H, Xing X W, Yuan J, Zhou Z Y, Luo X Y, Liu H M, Xie Y L, Yang L Q, Hong X B, Higgins P G, Wong N K. First identification of multidrug-resistant Acinetobacter bereziniae isolates harboring blaNDM-1 from hospitals in South China. Heliyon 2022 Dec, 9 (1), e12365.

11. Shafiq M, Zeng M, Permana B, Bilal H, Huang J, Yao F, Algammal AM, Li X, Yuan Y, Jiao X. Coexistence of blaNDM–5 and tet(X4) in international high-risk Escherichia coli clone ST648 of human origin in China. Front Microbiol. 2022 Nov 10;13:1031688.

12. Shafiq M, Yao F, Bilal H, Rahman SU, Zeng M, Ali I, Zeng Y, Li X, Yuan Y, Jiao X. Synergistic activity of tetrandrine and colistin against mcr-1-harboring Escherichia coli. Antibiotics (Basel). 2022 Oct 2;11(10):1346.

13. Shafiq M, Ke B, Li X, Zeng M, Yuan Y, He D, Deng X, Jiao X. Genomic diversity of resistant and virulent factors of Burkholderia pseudomallei clinical strains recovered from Guangdong using whole genome sequencing. Front Microbiol. 2022 Oct 28;13:980525.

14. Shafiq M, Rahman SU, Bilal H, Ullah A, Noman SM, Zeng M, Yuan Y, Xie Q, Li X, Jiao X. Incidence and molecular characterization of ESBL‐producing and colistin‐resistant Escherichia coli isolates recovered from healthy food‐producing animals in Pakistan. J Appl Microbiol. 2022 Sep 1;133(3):1169-82.

15. Huang W, Chang W. Newcastle Disease Virus/HK84: Next Potential Star for Targeted Immunotherapy of Hepatocellular Carcinoma? J Clin Transl Hepatol. 2022 Apr 28;10(2):179-180.

16. Bao M, Huang W, Zhao Y, Fang X, Zhang Y, Gao F, Huang D, Wang B, Shi G. Verapamil Alleviates Myocardial Ischemia/Reperfusion Injury by Attenuating Oxidative Stress via Activation of SIRT1. Front Pharmacol. 2022 Feb 23;13:822640.

17. Shafiq M, Huang J, Shah JM, Wang X, Rahman SU, Ali I, Chen L, Wang L. Characterization and virulence factors distribution of blaCTX‐M and mcr‐1carrying Escherichia coli isolates from bovine mastitis. J Appl Microbiol. 2021 Aug 1;131(2):634-46.

18. Bao Y, Zeng Q, Wang J, Zhang Z, Zhang Y, Wang S, Wong NK, Yuan W, Huang Y, Zhang W, Liu J, Lv L, Xue Q, Zha S, Peng Z, Yao H, Bao Z, Wang S, Lin Z. Genomic Insights into the Origin and Evolution of Molluscan Red-Bloodedness in the Blood Clam Tegillarca granosa. Mol Biol Evol. 2021 May 19;38(6):2351-2365.

19. Shafiq M, Huang J, Shah JM, Ali I, Rahman SU, Wang L. Characterization and resistant determinants linked to mobile elements of ESBL-producing and mcr-1-positive Escherichia coli recovered from the chicken origin. Microb Pathog. 2021 Jan 1;150:104722.

20. Zhou Z, Pan Q, Lv X, Yuan J, Zhang Y, Zhang MX, Ke M, Mo XM, Xie YL, Liu Y, Chen T, Liang M, Yin F, Liu L, Zhou Y, Qiao K, Liu R, Li Z, Wong NK. Structural insights into the inhibition of bacterial RecA by naphthalene polysulfonated compounds. iScience. 2020 Dec 17;24(1):101952.

21. Dang X, Wong NK, Xie Y, Thiyagarajan V, Mao F, Zhang X, Lin Y, Xiang Z, Li J, Xiao S, Noor Z, He Y, Zhang Y, Yu Z. Autophagy Dually induced by AMP surplus and oxidative stress enhances hemocyte survival and bactericidal capacity via AMPK pathway in Crassostrea hongkongensis. Front Cell Dev Biol. 2020 Jun 3;8:411.

22. Ruan Y, Wong NK, Zhang X, Zhu C, Wu X, Ren C, Luo P, Jiang X, Ji J, Wu X, Hu C, Chen T. Vitellogenin receptor (VgR) mediates oocyte maturation and ovarian development in the pacific white shrimp (Litopenaeus vannamei). Front Physiol. 2020 May 15;11:485.

23. Mao F, Wong NK, Lin Y, Zhang X, Liu K, Huang M, Xu D, Xiang Z, Li J, Zhang Y, Yu Z. Transcriptomic evidence reveals the molecular basis for functional differentiation of hemocytes in a marine invertebrate, Crassostrea gigas. Front Immunol. 2020 May 27;11:911.